Plantilla:Tab/Reparto
Personajes principales[]
- Jonny Lee Miller (Sherlock Holmes)
- Lucy Liu (Joan Watson)
- Aidan Quinn (Thomas Gregson)
- Jon Michael Hill (Marcus Bell)
- John Noble (Mr. Morland Holmes)
Estrellas invitadas[]
- Jeremy Bobb (Gary Burke)
- Sean Cullen (Samuel Meher)
- Marin Ireland (Alta Von See)
- Geoffrey Cantor (Maurice Antonov)
- Christian DeMarais (Test Subject/Ollie Tate)
- Lisa Ferreira (Assistant)
- Rudy Mungaray (Agent Marco Saveda)
- Wayne Chang (Dan Zheng)
- Ron Nakahar (Mr. Xiaoping)
- Roya Shanks (U.S. Attorney)
- Sarah Dacey Charles (Lawyer)